Both #1 Villanova and #2 Virginia were defeated in the Round of 32 in the East Regional. This marks the 6th time since the field expanded to 64 that both the #1 and #2 seeds failed to advance to the Sweet Sixteen.
- 1990 Midwest - #1 Oklahoma, #2 Purdue
- 1992 Midwest - #1 Kansas, #2 Southern California
- 2000 South - #1 Stanford, #2 Cincinnati
- 2000 West - #1 Arizona, #2 St. John's
- 2004 Midwest - #1 Kentucky, #2 Gonzaga
- 2015 East - #1 Villanova, #2 Virginia
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